Anne Kaster

Biotechnology and Microbial Genetics

The Kaster lab uses innovative methods like single cell omics to investigate so far uncharacterized prokaryotic species. We are especially interested in microorganisms with a potential for biotechnological applications, such as novel natural product producers or bioremediators.

Cell Adhesion Molecules (CAM) and Signal Transduction Pathways

Stringent regulation of signaling pathways is essential for development and homeostasis. Deregulation within these signaling pathways leads to pathological consequences. In our group, we investigate the functions of cell surface receptors, such as cell adhesion molecules (CD44), receptor tyrosine kinases (MET, VEGFR-2, EGFR,...), G-protein receptors (CXCR4) or LRP6 (Wnt signaling pathway), in various inflammatory diseases, including non-alcoholic liver disease, multiple sclerosis and cancer. Among other things, we are interested in the influence of these molecules on stem cell capacity and cell plasticity. In close collaboration with chemists and physicians, we are developing methods to specifically inhibit cell surface receptors such as CD44. A peptide identified in our laboratory is already in clinical test phase I/Ib.